Ancestry informative markers for Asian subcontinent
نویسندگان
چکیده
منابع مشابه
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease.
The β(s) mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the genetic structure of a population. In this study, we have estimated the g...
متن کاملA panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications.
Autosomal ancestry informative markers (AIMs) are useful for inferring individual biogeographical ancestry (I-BGA) and admixture. Ancestry estimates obtained from Y and mtDNA are useful for reconstructing population expansions and migrations in our recent past but individual genomic admixture estimates are useful to test for association of admixture with phenotypes, as covariate in association ...
متن کاملA Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population
Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The predominant population group in the Western Cape, South Africa, is the admixed group known as the South African Coloured (SAC). A small set of AIMs that i...
متن کاملInferring Geographic Coordinates of Origin for Europeans Using Small Panels of Ancestry Informative Markers
Recent large-scale studies of European populations have demonstrated the existence of population genetic structure within Europe and the potential to accurately infer individual ancestry when information from hundreds of thousands of genetic markers is used. In fact, when genomewide genetic variation of European populations is projected down to a two-dimensional Principal Components Analysis pl...
متن کاملCoAIMs: A Cost-Effective Panel of Ancestry Informative Markers for Determining Continental Origins
BACKGROUND Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Forensic Science International: Genetics Supplement Series
سال: 2017
ISSN: 1875-1768
DOI: 10.1016/j.fsigss.2017.09.091